Category: ‘Research for a Cure’


Epigenetic Treatment in Mice Improves Spinal Cord Regeneration After Injury

Posted on September 22nd, 2022

Synapses and motoneurons in the spinal cord.
Increased density of synapses (green) that contact motoneurons (purple) in the spinal cord of an injured animal after treatment with the small molecule TTK21-These are important for motor function. Image credit: Franziska Mueller (CC-BY 4.0)

New Imperial-led research shows that weekly epigenetic treatment in mice can support spinal cord regeneration after severe injury.

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Restoring Movement After Spinal Cord Injury Focus of New Research

Posted on September 7th, 2022

Spinal Stimulation
Ismael Seáñez will lead an interdisciplinary team of Washington University researchers and physicians to understand the changes in the neural circuits that may result in motor function improvements through using spinal cord stimulation. (Photo: Whitney Curtis/Washington University)

People with spinal cord injuries often experience life-long movement impairment or paralysis, for which there is no cure. When coupled with rehabilitative exercise, electrical spinal cord stimulation can help restore some movement, though the mechanisms of how the nerves in the spinal cord recover are unknown.

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Untapped Potential of Stem Cells Could Aid Repair of Spinal Cord Damage

Posted on August 23rd, 2022

Scientists at the Francis Crick Institute have identified a group of latent stem cells that respond to injury in the central nervous system of mice. If a similar type of cell exists in humans, they could offer a new therapeutic approach to treat brain and spinal cord injuries.

Mouse brain, with ependymal cells.
Image of mice brain, with ependymal cells shown in red. – Alessandro Ciccarelli and Bruno Frederico

After disease or injury, stem cells help repair the damage by replacing cells that have died. In some organs, like the skin and intestine, these stem cells are constantly active, while in others, so called ‘latent stem cells’ lie waiting for harm to occur before being triggered into action.  

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Breakthrough Treatment Developed to Help Spinal Cord Injuries

Posted on August 15th, 2022

A team of researchers in Switzerland have developed a breakthrough technology that could assist in a cure for paraplegia.


Research Shows Cancer Drug Fosters Nerve Repair After Injury

Posted on July 18th, 2022

Scientists from the University of Birmingham have shown that a brain-penetrating candidate drug can foster regeneration of damaged nerves after spinal trauma.

Nerves

The research, published today in Clinical and Translational Medicine, used cell and animal models to demonstrate that when taken orally the candidate drug, known as AZD1390, can block the response to DNA damage in nerve cells and promote regeneration of damaged nerves, so restoring sensory and motor function after spinal injury.

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